摘要
目的比较不同年龄患儿异丙酚的药代动力学。方法35例ASA Ⅰ或Ⅱ级患儿根据年龄不同分为3组,A组:<3岁;B组:≥3岁且<5岁;C组:≥5岁且<10岁。单次静脉注射异丙酚3 mg·kg-1后2、4、6、8、10、20、30、45、60、90、120、180 min抽取桡动脉血1 ml,高效液相色谱法检测血浆异丙酚浓度,经计算机软件拟合,得到各项药代动力学参数。结果三组患儿单次静脉注射异丙酚3 mg ·kg-1后血浆浓度下降迅速。与C组相比,A组的消除项指数常数较小,消除半衰期较长(P<0.01)。三组患儿的中央室分布容积分别为0.55、0.60、0.58 L·kg-1;总体清除率分别为0.015、0.016、0.020 L·kg-1·min-1;总体分布容积分别为8.0、6.5、6.2 L·kg-1,分布半衰期和速率常数(K12、K21、K10),组间比较差异均无统计学意义(P>0.05)。结论小于3岁患儿单次静脉注射3 mg·kg-1异丙酚后其药代动力学过程符合三室开放模型,除消除时间有所延长外,其余药代动力学参数与较大患儿一致。
Objective To investigate the pharmacokinetics of propofol in children of different ages after a single dose. Methods Thirty-five ASA Ⅰ or Ⅱ children were divided into 3 age groups： group A 〈 3 yr; group B≥3- 〈 5 yr and group C≥5- 〈 10 yr. Arterial blood samples of 1 ml were obtained at 2, 4, 6, 8, 10, 20, 30,45, 60, 90, 120, 180 min after a bolus dose of propofol （3 mg· kg^-1）. The plasma concentrations （Cp） of propofol were measured by using high performance liquid chromatograph with ultraviolet detector. The data obtained were analyzed by 3P87 pharmacokinetic software. Results The Cp of propofol decreased rapidly after intravenous bolus injection in all 3 groups. The curve for Cp vs time was fitted to a three-compartment pharmacokinetic model.Group A had a significantly smaller mean exponent γ（ P 〈 0.01 ） leading to a significantly longer mean elimination half-life gamma （T1/2 γ） compared with group C. There were no significant differences in central volume of distribution （Vc）, total clearance （CL）, apparent volume of distribution （Vd） and other parameters including rate constants K12, K21 , K10 among the 3 groups. Conclusion The Cp versus time curve for propofol is best described by a three-compartment pharmacokinetic model. Elimination of propofol is prolonged in children less than 3 yr of age.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2005年第6期425-427,共3页
Chinese Journal of Anesthesiology
基金
浙江省医药卫生优秀青年科技人才专项基金
