摘要
用ｎｍ２３多克隆抗体对６２例颊癌进行了免疫组化研究。结果：有转移组阳性率为３１．０％（９／２９），无转移组的阳性率为５７．６％（１９／３３）；病理分级Ｉ级的阳性率为５９．４％（１９／３２），Ⅱ级为３７．５％（６／１６），Ⅲ级为２１．４％（３／１４）；患者生存年限少于３年、３～５年和５年以上的阳性率也有逐渐增高趋势，但无统计学意义（Ｐ＝０．１２６）．结果表明，ｎｍ２３表达水平与颊癌颈淋巴结转移和预后有关。
In this study weused
immunohistochemistry stain for polyclone anti-body nm23 in 62 cases of buccal carcinoma. The
re-sults showed that both the epithelium of mucosa andthe duct epithelium of minor salivary
gland nearby thetumor were strong positive. The stains on tumor cellswere various. 31. 0%
(9/29) of the cases with lymph-node metastasis were positive while 57. 6% (19/33) of0. 044).
Histologically, 59. 4 %(19/32) of the caseswere positive in Grade I , while 37. 5 % ( 6/16 )
positivein Grade Ⅱ and 21. 4%(3/14) in Grade Ⅲ(P =0. 048). The positive rate increased with
the patientssurvival time from less than 3 years to 3-5 years andmore than 5 years
correspondingly, but there was nostatistical significance (P=0. 126). The results sug-gested that
the expression of nm23 might be one of thefactors influencing the lymph-node metastasis and
出处
《华西医科大学学报》
CSCD
1995年第4期367-370,共4页
Journal of West China University of Medical Sciences
基金
国家自然科学基金
关键词
NM23基因
颊癌
免疫组化
转移抑制基因
nm23 gene Buccal cancer Immunohistochemistry stain The Project Supported by
National Vatural Science Foundation of China
