摘要
以人舌鳞癌TCa8113细胞作为术中脱落癌细胞的模型,观察盐酸氮芥、平阳霉素、氨甲喋呤、顺氯氨铂、5氟尿嘧啶对癌细胞作用5min时的杀伤效应。实验结果表明:1.化疗药物短时间内对癌细胞的杀伤数及有丝分裂抑制有明显差异,2.除5氟尿嘧啶外,癌细胞再次体外培养时均不能增殖,结果提示临床上应用氮芥、平阳霉素、氨甲喋呤及顺氯氨铂作为冲洗液,能有效地抑制术中脱落的癌细胞。
Abstract The authors used the human's tongue cell line(Tca 8113)as an experimental modle in vitro to study the cell immediate killed effect of commonly used anticancer drugs after exposure 5 minutes.The results were as follows:1.The numbers of living cell reduced significantly,so did the indeces of mitoses.2.All the drugs except 5-Fu could utlerly kill the cells.The results indicated that clinical irrigation of surgical wound with HN2,PYM and DDP solution could effectively prevent tumor recurrence after surgery.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
1995年第3期151-153,共3页
West China Journal of Stomatology