摘要
试验采用１２０只小鼠，每只感染１１６条脱囊幼虫。用于治疗的９６只１１、鼠分为４×４组，分别按旋毛虫的４个不同发育阶段分别１次肌肉注射３０，５０，７５和１００ｍｇ·ｋｇ￣（－１）丙硫咪唑缓释注射剂，结果肠内脱囊期幼虫减少均为１００％；肠内成虫减少率分别为７９％，９０．３％，９４．３％和９９．２％；移行期幼虫减少率分别为８７．２２％，８９．９４％，９３．１６％和９５．２４％；成囊期幼虫减少率分别为９０．５％，９４．４８％，１００％和９４．１８％。各治疗组与对照组比较均有极显著差异。试验结果表明，按３０ｍｇ·ｋｇ￣（－１）～１００ｍｇ·ｋｇ￣（－１）剂量给小鼠１次肌肉注射丙硫咪唑缓释注射剂，对各发育阶段的旋毛虫均有显著的杀虫效果。使用该制剂具有用药量小，疗效高，给药次数少，使用安全等优点。
this is a report of the treatment of infected mouse trichinosis by slow release al-bendazole injection. Each mouse was infected with 116 Larvae of Trichinella spirali Theinfected 96 mice for treatment were divided into 4 × 4 groups. Each group was treated in-tramuscularly with one dose of the drug at 1 hour, 3,12 and 30 days after the infection,bythe dosage of 30,50,75 and 100mg,kg￣(-1) weight respectively. The mice were sacrificed andexamined on 6,6 , 35 and 50 days after the treatment respectively. Compared with the un-medicated infected controls, the encysted larvae reduction rates of the different dosageswere all 100%;And the adult worm reduction rates were79%,90.3%,94.3%and 9.2%respectively; the invasive iarvae reduction rates were 8.2%, 89.94%,93.16%and95.24%respectively;the encysted larvae reduction rates were 90.5%, 94.48%, 100%and94.18%respectively. They were significantly different from those of the control mice(P<0.01). These experimental results suggested that significant therapeutic efficacy againstTrichinella spiralis of different stages might be obtained intramuscularly with one dose of30～100mg·kg￣(-1) weight of slow releasealbendazole injection. This preparation has theadvantages of small amount of dosage,better the therapeutic efficacy , low frequency ofdosages and reliability of application。
出处
《河南农业大学学报》
CAS
CSCD
1995年第4期396-399,共4页
Journal of Henan Agricultural University
