摘要
低氧（营养液通入９５％Ｎ２＋５％ＣＯ２）可收缩离体猪冠状动脉。氧化氮（ＮＯ）供体ＳＩＮ—１０．１、１和１０μｍｏｌ·Ｌ－１可浓度依赖性地抑制低氧收缩作用。钙通道阻断剂维拉帕米（Ｖｅｒａｐａｍｉｌ）０．１和１μｍｏｌ·Ｌ－１亦可浓度依赖性地抑制低氧收缩离体猪冠脉的作用。
Hypoxia (K-H solution aired with 95 %N2+5 %CO2) could induce the contraction of the isolated pig coronary artery. 3- morpholinosydnonimine (SIN-1), a donor of nitric oxide 0.1, 1 and 10 μmol. L-1, inhibited the hypoxia-induced contraction in a concentration-dependent manner. Verapamil, a calcium antagonist 0. 1 and 1 pmol-1 could also decrease the hypoxia-induced contraction of the isolated pig coronary artery in dose-dependent manner.
关键词
氧化氮
维拉帕米
低氧
冠状动脉
nitric oxide
verapamil
coronary vessels
hypoxia
