摘要
应用醋酸氢化可的松在小鼠体内复制肾阴虚证模型及在造型时给予补肾中药，以观察造型及补肾中药对免疫指标胸腺、脾脏重量及脾细胞ＩＬ一２活性的影响。结果表明：造型使上述免疫指标降低，与正常对照组比较差别有非常显著性意义（Ｐ＜０．０１）；补肾阴中药对造型所致的免疫指标改变具有拮抗作用，与造型组比较每项指标差别都有非常显著性意义（Ｐ＜０．０１）。补肾阳中药则未见明显拮抗作用，反而使胸腺重量减轻更加明显，与造型组比较差别有非常显著性意义（Ｐ＜０．０１）。结果提示，免疫功能低下可能是肾阴虚证重要的病理变化之一；通过辨证施治给予补肾阴中药可以调整其机体的免疫功能，并通过神经内分泌免疫网络产生相互作用，这可能是治疗肾阴虚证的重要药理学基础。
The weight of thymus and spleen and the IL 2 activity of spleen cell were used as criteria for estimating the influence of kidney一yin modelling(by hydrocortison injection ) and kidney一tonifying herbs on immunologic function of mice. The results showed that the weight of thymusand spleen and the IL一2 activity of spleen cell in modelling group were significantly reduced ascompared with control group(P<0. 01).The kidney一yin tonifying herbs antagonized theinfluence of modelling on the immunogical criteria, while the kidney一yang tonifying herbs had nosuch action, It is suggested that a low immunologic function may be one of the importantpathological changes of kidney一yin deficiency syndrome, and the modulation of immunologicfunction and the interaction through neuro一endocrine一immunity network system may be theimportant pharmacologic basis for the kidney一yin tonifying herbs.
关键词
肾阴虚
中医药疗法
补肾药
淋巴细胞
免疫学
KIDNEY YIN DEFICIENCY/TCM ther.KIDNEY一REINFORCING DRUGS/ther.use MITOGENIC FACTORS, LYMPHOCYTE /immunol. DISEASE MODELs, ANIMAL MICE
