摘要
利用减压舱模拟８０００ｍ低氧和放射免疫的方法，观察了大鼠脑内环—磷酸腺苷（ｃＡＭＰ）和环—磷酸鸟鲁（ｃＧＭＰ）含量的变化。以西宁地区的海拔２２６０ｍ作为对照，并进行比较。结果发现，海拔８０００ｍ低氧时，大鼠脑内ｃＡＭＰ含量明显升高。同海拔高度比较，小脑ｃＡＭＰ的含量明显高于大脑皮层内的含量（Ｐ＜０．０１）。尽管小脑ｃＧＭＰ的含量在８０００ｍ组明显升高，但在同海拔高度小脑与大脑皮层ｃＧＭＰ的含量间无显著性差异。本研究结果提示脑内环核苷酸的含量是脑缺氧反应的敏感指标，而且以ｃＡＭＰ的反应更灵敏。
e observed the content of
cyclic nucleotide in rat brain in decompression chamber with
radioim-munoassay(RIA)and compared the difference of the content
between cerebral cortex and cerebellum.The content of cAMP and cGMP
of simulated 8 000m group was compared with 2 260m group atXining.The
results showed that the cAMP content was increased in both cerebral
cortex and cerebel-lum at 8000m hypoxia and it was higher in
cerebellum than cerebral cortex.The content of cGMPwas increased only
in cerebellum at 8 000m.The results syggest that the coiitent of
cyclic nucleotidesis a susceptible parameter for hypoxia.
出处
《高原医学杂志》
CAS
1995年第2期20-21,共2页
Journal of High Altitude Medicine
关键词
低氧
脑
环核苷酸
高山反应
hypoxia
cAMP,cGMP:cerebral cortex
cerebellum
