摘要
应用ＰＣＲ／ＲＦＬＰ方法对广东籍２２名正常人及２０名胰岛素依赖型糖尿病人（ＩＤＤＭ）进行了ＨＬＡ－ＤＱＢ１等位基因分型。结果：在ＤＱＢ１等位基因中未发现单独出现于ＩＤＤＭ的类型；全部等位基因中正常对照组与ＩＤＤＭ组间均无显著性差异；非Ａｓｐ－５７编码的ＤＱＢ１等位基因与广东籍ＩＤＤＭ病人不相关；广东籍ＩＤＤＭ的免疫遗传基因可能在ＨＬＡ－ＤＱＢ１以外的其它位点。
In tbis paper,we used PCR/RFLP method toanalyse the genetic
polymorphism of HLA-DQB1gene of controls and IDDM patients in Guangdong,Chi- na. The
study suggests:(1)In all the DQB1 alleles investigated,not any single one is related to the
occur- rence of IDDM;(2)there is no significant difference between the percentages of the
various alleles of thenormal control group and the IDDM group;(3)aspartic acid at position 57 of
HLA- DQB1 in Guangdong isnot associated with the susceptibility to IDDM. In short,the
preliminary study suggests that the suscepti- bility to IDDM in Guangdong may exist at other
locus of the HLA genes rather than DQ B1.
出处
《第一军医大学学报》
CSCD
1995年第1期15-18,共4页
Journal of First Military Medical University
关键词
糖尿病
白细胞抗原
基因
多态性
聚合酶链反应
insulin- dependent diabetes
mellitus(IDDM)
HLA- DQ genes
restriction fragment length polymorphism(RFLP),polymerase
chain reaction(PCR)
