摘要
目的：探讨高渗盐水复苏对失血性休克兔脏器血流量的影响及机理．方法：健康家兔按２０ｍｌ／ｋｇ体重放血致失血性休克，６０ｍｉｎ后，分别回输１０％放血量的抗凝自体全血（自血）、生理盐水及高渗盐水，记录不同时刻颈动脉压，采用放射性微球技术检测动物心、肾、胃及空肠血流量．结果：高渗盐水复苏后，失血性休克家兔平均动脉压迅速提高，脏器血流量增加，显著高于缺血对照组（Ｐ＜０．０５或Ｐ＜０．０１）．结论：高渗盐水复苏失血性休克，可迅速提高动物平均动脉压，改善脏器灌流．
Objective:The study was
designed to investigate the mechanism of changes in vesceral blood flowfollowing
resuscitation from hemorrhagic shock in rabbits with hypertonic saline. Methods:Thirty
rabbitswere divided into five groups at random. Sixty minutes after blood letting in a volume of
20 ml/kg bodyweight, heparinized blood, normal saline and 1282 mmol/L NaCl were separately
administered in a volumeapproximating 10% of shed blood volume. The mean arterial
pressure(MAP)were recorded during the ex-perimental procedure. The vesceral blood flow
measurements were obtained by radioactive microsphere tech-nique. Results:The vesceral
blood flow and MAP in rabbits were significantly(P<0. 05 or P<0.01)greater in hypertonic saline
group than in the ischemia control group after resuscitation. Conclusion:Hyper-tonic saline may
increase vesceral blood flow and MAP quickly following resuscitation from hemorrhagicshock
in rabbits.
出处
《第四军医大学学报》
1995年第3期226-228,共3页
Journal of the Fourth Military Medical University
关键词
盐水溶液
高渗
复苏
失血性休克
休克
血流量
saline solution,hypertonic
resuscitation
shock
hemorrhagic
blood
circulation
rabbits
