摘要
采用D-Gal将大鼠做成实验性肝坏死,分别以ATP及ATP-MgCl2治疗结果表明,ATP-MgCl2组无一死亡,[3H]TdR肝内掺入量与模型组比较有极显著差异（P<9.01）,肝坏死程度较轻,在残存的肝细胞浆中肝糖原颗粒和线粒体数量较对照组及ATP组更为丰富,且超过正常组。提示对急性肝坏死尽早使用ATP-MgCl2,可减轻肝脏坏死程度,并促进肝细胞蛋白质及DNA的合成,从而加速肝细胞的再生和修复。
The experimental hepatic necrosis induced by D-galactosamine was treated by ATP and ATP-MgCl2, respectively.The results showed that the degree of hepatic necrosis in the ATP-MgCl2 group was milder than that in the control group and ATP group.It is suggested that ATP-MgCl2 could reduce the hepatic jnjury and accelerate the regeneration of the hepatic cells in the experimental hepatic injury.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1989年第2期145-147,159,共4页
Academic Journal of Second Military Medical University
关键词
氨基半乳糖
肝坏死
ATP-MGCL2
D-galactosamine
hepatic necrosis
ATP-MgCl_2
disease models,animal
