摘要
福氏完全佐剂致炎后ｄ１９～ｄ２３ｉｇ给药，ＫＧ８８１１０、２０ｍｇ·ｋｇ－１·ｄ－１在给药后ｄ７均显著降低佐剂性关节炎（ＡＡ）大鼠非致炎侧的足肿胀度，病理组织学检查发现，ＫＧ８８１１０、２０ｍｇ·ｋｇ－１·ｄ－１使ＡＡ大鼠非致炎侧踝关节的水肿和炎细胞浸润明显减轻。用角叉菜胶诱发大鼠足爪肿胀，致炎前９０ｍｉｎｉｇ给药，ＫＧ８８１５、１０、２０ｍｇ·ｋｇ－１·ｄ－１均显著抑制大鼠的足爪肿胀。这些结果表明，ＫＧ８８１有抗炎作用。
The hind paws of rats were injected intracutaneously with Freund's complete adjuvant (FCA).Drugs and vehicle were administered intragastrically on day 19 to 22 after FCA injection. KG881 at doses of 10 and 20 mg gold·kg-1·d-1 produced a significant suppression of uninjected hind paw edema of adjuvant arthritic rats on day 7 after the administration of drugs.The reduction of edema and the infiltration of inflammatory cells in the uninjected ankle of adjuvant arthritic rats was found by means of the pathohistological examination.Ingastical administration of KG881 at equivalent gold doses for 90 min befor carrageenan injection markedly inhibited the carrageenan-induced acute inflammation in rats.These results indicate that KG881 can be used to treat the adjuvant arthritis in rats.
出处
《安徽医科大学学报》
CAS
1995年第1期7-9,共3页
Acta Universitatis Medicinalis Anhui
关键词
抗炎剂
类风湿性关节炎
药理学
KG881
antiflammatory agents
adjuvant pharmaceutic
carrageenan
arthritis
rat
KG881
auranofin
FCA
