摘要
氧氟沙星系喹诺酮类衍生物之一。国内首次应用于治疗110例细菌性感染患者,其中呼吸系感染63例、单纯性及复杂性尿路感染分别为23及24例。剂量为100mg,每日1-3次,疗程3-22d。1 0例中分离到病原菌114株,98株为革兰阴性菌。治疗后临床有效率为86.4％,病原菌清除率为86.8％,不良反应发生率7.7％,表现为皮疹,心悸,失眠。本品抗菌谱广,抗菌活性强,口服吸收完全,有肯定的疗效及耐受性强。适用于各种细菌性感染,不宜用于孕妇及小儿。
Ofloxacin, a fluorinated quinolones was used to treat 110 patients with various infections, among whom 63 patients suffered from respiratory tract infections, while 23 and 24,simple and complicated urinary tract infections respectively. One hundred and fourteen strains of bacteria were isolated with 98 Gram-negative. Ninety-five patients(86.4%)showed quite effective therapeutic responses clinically. The chance of bacteriological eradication-rate was 86.8%. It can be well tolerated by most patients without trouble. Nine patients developed various skin-rashes,insomnia and/or palpitation.
出处
《新药与临床》
CSCD
北大核心
1989年第5期257-260,共4页
关键词
氧氟沙星
呼吸道感染
尿路感染
ofloxacin
respiratory tract infections
urinary tract infections
