摘要
本文采用重用大黄中西医结合治疗出血坏死性胰腺炎２５例，结果提示：有效１９例，有效率７６％；手术４例，手术率１６％；死亡６例，死亡率２４％。与单纯用西药治疗相比较，可减少并发症，降低手术率与死亡率；实验研究结果：①从大黄中找到了８个有效单体对胰蛋白酶等多种胰酶具有明显抑制作用，初步找到了大黄治疗急性胰腺炎的物质基础；②建立和改进了４种动物模型，从亚细胞水平阐明了大黄对胰腺细胞有直接的保护作用。在电镜下观察到胰腺细胞的修复及紧密连接处恢复正常。同时根据大黄对内毒素血症、血液流变性前列腺素、血栓素、厌氧杆菌等多方面的作用，阐明了大黄防治胰腺炎的间接作用。
n the study 25 patients with acute hemorrhagic
necrotizing pancreatitis were treated withlarge doses of rhubarb and conventional treatment of
western medicine. The results showed thatthe effective rate was 76%, operation rate l6%and
mortality rate 2.4%。 With large dose ofrubarb,the course of treatment was shorter than that with
western drugs alone and the operationrate and mortality were also lower. Rh ubarb could protect
the cell membrane of the pancreas.
出处
《中国中西医结合外科杂志》
CAS
1995年第3期130-132,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
