摘要
以抗结肠癌及胃癌单克隆抗体组合应用对１８０１例进行胃肠癌普查。普查结果：３２例胃肠癌肿瘤相关抗原阳性，阳性率为１．８％，部分进行胃及肠镜检查，其中１２例做肠镜，３０例做胃镜，结果证实：早期胃癌１例。癌前病变１９例，其中大肠腺瘤５例，伴不典型增生２例，萎缩性胃炎１２例，伴不典型增生７例，浅表性胃炎伴不典型增生１例，老年多发性肠憩室１例。此外，非癌前病变７例，包括浅表性胃炎、急性胃、肠炎等。１７５０例阴性者随访１年以上，尚未发现胃、肠癌，本法假阳性率低，０．３％。且方法较简便、价低。用于胃肠癌普查及诊断将有一定意义。
Gastrointestinal carcinoma is one of the top eight malignant diseases in
term of inci-dence or cancer deaths in China. The most critical element of improved survival for
cancer pati-ents is early diagnosis. To find an accurate,simple,rapid and conveneint test is
necessary. Weset up a methods,using electrophoresis and enzyme labeled antibody staining
assay with threemonoclonal antibodies against colorectal and gastric cancer.The mass
screening by this assay wasperformed in 1801 cases.The results showed:thirty two cases
were positive in 1801 persons,thepositive rate was 1.8%.After GI endoscopic and histological
examinations,the final diagnosiswere:one case of early gastric cancer.19 cases of
pre-malignant lessions,5 of them were colonadenomas,12 were chronic atrophic gastritis,1 was
chronic supcrficial gastritis with dysplasia,1was multiple diverticulosis in an old man and 7
cases were non-malignant diseases,The palsepositive rate was 0.3%. After follow-up for more
than one year no cancer was found in theother negative 1750 cases.This preliminary results
show that this method may be useful in massscreening and early diagnosis of gastrointestinal
carcinoma.
出处
《军医进修学院学报》
CAS
1995年第1期24-26,共3页
Academic Journal of Pla Postgraduate Medical School
关键词
单克隆抗体
诊断
胃肠道肿瘤
流行病学
monoclonal antibodies
diagnostic use
gastrointestinal
neoplasms
epidermiology
