摘要
静脉一次性注射单克隆抗体5-1-6可引起实验大鼠大量的、一过性的蛋白尿。抗体注射后第1、3、5、8天,柴胡剂治疗组与PBS对照组比较有显著性差异。免疫荧光所见,柴胡剂治疗组中沿肾小球毛细血管壁颗粒样沉积明显减少。口腔灌药柴苓汤对蛋白尿的作用未能得到证实。此实验提示柴胡剂可能通过某种途径改变了大鼠肾小球毛细血管壁的通透性。
A one - dose 5 - 1 - 6 monoclonal antibody injected intravenously can induce atransient massive proteinuria in rat. Comparison between Radix Bupleuritreating group and PBS control group 1, 3, 5, 8 days after injection showed significant difference. Under immuno -flourescence exam, the granular precipitation along the glomerular capillaries in experimental group decreased distinctively, yet the effect of Chailing Decoction on proteinuria can not be proved by oral infusion, suggesting that Radix Bupleuri may change the permeability of glomerular capillary in rat through certain mechanism.
出处
《中医杂志》
CSCD
北大核心
1995年第7期424-425,共2页
Journal of Traditional Chinese Medicine
关键词
蛋白尿
中医药疗法
单克隆抗体
柴胡剂
Proteinuria/TCM therapy antibody, monoclone @ Injectionof Radix Bupleuri
