摘要
本组采用随机对照方法观察恩丹西酮（齐鲁）的止吐作用。凡第１次接受含环磷酰胺、阿霉素的联合方案后出现呕吐的患者入组，第２次化疗时随机用恩丹西酮或用对照药（胃复安或枢复宁），第３次化疗时交换。共１５５例患者入组。结果显示，恩丹西酮第１天的止吐有效率为８７．７％，胃复安为６１．６％；平均呕吐次数分别为０．８次／日和２．７次／日（Ｐ＜０．０１）。恩丹西酮与枢复宁比较止吐效果相似。恩丹西酮对非顺铂化疗引起的呕吐具有很好的止吐效果，副作用小。
AbstractThe antiemetic
effect of ondansetron(supplied by Qilu Pharmaceutical Company)in
patients re-ceiving non-cisplatin chemotherapy(containing CTX and/or
ADM ) was studied in a multiple centre,randomized cross-over trial.
The patients who had vomiting in the first turn of chemotherapy
enteredthe trial. The patients recieved randomly ondansetron or
control drugs-metoclopramide or Zofran(Glaxo ) in the second turn of
chemotherapy. In the third , the patients were cross-over to use
theother antiemetic drug.A total of 155 patients were enrolled into
the study. The results showed , theeffective control rate(0～2emetic
episodes) on the first day were 87.7%of patients treated with
on-dansetron and 61.6%treated with metoclopramide. The mean frequency
of vomiting was 0.8 timesin ondansetron and 2.7 times in
metoclopramide(P<0.01 ). Ondansetron was superior to metoclo-pramide
for the control of emesis. The antiemetic effects of
ondansetron(Qilu)and Zofran(Glaxo)were very similar.The side-effects
of ondansetron were mild.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1995年第4期294-297,共4页
Chinese Journal of Oncology
