摘要
１２０例由组织学或／和细胞学诊断的恶性胸腔积液，经胸腔内灌注顺铂（ＤＤＰ）５００～１０００ｍｇ，静脉滴注硫代硫酸钠（ＳＴＳ）（第１天１６～３２ｇ，第２～３天８～１６ｇ）解救，即“双途径化疗”（ＴＲＣ），共计１６８个疗程。每位患者经１～４个疗程治疗，其中胸水及肺内癌灶同时消失（特效）６例，占５％；胸水完全消失（显效）８３例，占６９．２％；胸水消退过半在１个月内无须再次抽胸水（有效）１９例，占１５．８％；在１个月内须再次抽胸水（无效）１２例，占１０％；总有效率９０．０％，（１０８／１２０）。毒副反应：胃肠道反应Ⅲ度３２例，Ⅳ度１４例，占３８．３％；肾毒反应Ⅲ度６例，Ⅳ度２例，占６．７％；骨髓反应Ⅲ度８例，Ⅳ度４例，占１０％，其中２例死亡，余者经过治疗２～３周内恢复。缓解期１～３２个月，平均６．４个月。存活超过６个月者７４例，占６１．７％。与其它胸水治疗方法比较，该方法具有较突出的疗效。
ne hundred twenty cases of
malignant pleural effusion were treated by intrapleural
administra-tion of large doses of DDP(500～1000mg)followed by iv
infusion of sodium thiosulfate for 3 days.Each patient received 1～
4cycles of treatment.Of 120 cases,89 had their effusion completely
disap-peared and in 6 of them,it was accompanied by complete
regression of tumors in the lung. Partial re-sponse was observed in
19 cases with an overall response rate of 90.0%. The median remission
periedwas 6.4 month.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1995年第1期50-52,共3页
Chinese Journal of Oncology
关键词
恶性胸腔积液
药物疗法
顺铂
硫代硫酸钠
肺肿瘤
evere(grade Ⅲ and Ⅳ)gastrointestinal,
renal
toxicity and myelosuppression oc-curred in 46,8 and 12
cases,respectively,Two patients died of severe intoxication.
