摘要
用放射免疫法测定了东莨菪碱对吗啡成瘾大鼠下丘脑、垂体和血浆β内啡肽样免疫活性物质（ｉｒ－β－ＥＰ）和催产素样免疫活性物质（ｉｒ－ＯＴ）含量的变化。结果表明：（１）吗啡成瘾后，大鼠下丘脑、血浆中ｉｒ－β－ＥＰ和ｉｒ－ＯＴ含量增加（Ｐ＜０．０１），而垂体中ｉｒ－β－ＥＰ和ｉｒ－ＯＴ含量降低（Ｐ＜０．０１），提示大鼠脑内β－ＥＰ和ＯＴ含量的改变可能与吗啡的依赖和耐受产生有关。（２）东莨菪碱治疗３天和４天后，下丘脑中ｉｒ－β－ＥＰ含量增加（Ｐ＜０．０１），但ｉｒ－ＯＴ含量降低（Ｐ＜０．０１），垂体中ｉｒ－β－ＥＰ和ｉｒ－ＯＴ含量增加（Ｐ＜０．０１），提示东莨菪碱可能通过改变大鼠脑内下丘脑－垂体轴β－ＥＰ和ＯＴ的含量从而减轻对吗啡的依赖和耐受的产生。
ale Sprague-Dawley rats
weighing 180 ～ 220gwere rendered dependent on morphine by repeated injec-tions of
morphine in increasing doses for 14 days. 0. 3mg/kg of scopolamine was injected
intraperitoneally bidfor 3 and 4 days. Control rats were similarly injectedwith saline. The
contents of β-endophin (β-EP) andoxytocin (OT) in hypothalamus, pituitary and plasmawere
measured by radioimmunoassay. The resultsshowed that both β-EP and OT in hypothalamus
andplasma increased but both were decreased in pituitary inmorphine dependent rats (P<0.01) .
After scopolaminetreatment, the contents of β-EP increased but OT de-creased in
hypothalamus (P<0. 01) , and both elevatedsignificantly in pituitary(P< 0.01). The results
sug-gested that scopolamine might modulate hypothalamus-pituitary system to affect the
realease or synthesis of β-EP and OT in the brain.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1995年第1期8-10,共3页
National Medical Journal of China
关键词
下丘脑
东莨菪碱
吗啡瘾
内啡肽类
戒毒
Scopolamine Morphine
addictionHypothalamus Endophin Oxytocin
