摘要
作者对２６例大肠癌病人肿瘤及癌旁粘膜匀浆中的生长抑素（ＳＳ）水平进行了ＲＩＡ检测，并对ＳＳ阳性细胞（ＳＰＣ）进行了免疫细胞化学观察。结果表明：癌远旁粘膜（ＣＤＭ）中平均ＳＳ水平高于癌组织，低于癌近旁粘膜（ＣＡＭ），相差非常显著（Ｐ＜０．０１）．高分化癌（乳头状腺癌和管状腺癌Ⅰ级）、粘液腺癌中平均ＳＳ水平均显著高于中分化癌（管状腺癌Ⅱ级，Ｐ＜０．０１和０．０５）及低分化癌（管状腺癌Ⅲ级，Ｐ＜０．０５）；除粘液腺癌外，癌分化越好，ＳＳ水平越高（ｒｓ＝０．４６３，Ｐ＜０．０５）。ＣＡＭ中，无异型增生者平均ＳＳ水平高于有异型增生者，差异有非常显著性（Ｐ＜０．０１）；ＳＳ水平与异型增生程度间呈非常显著之负相关（ｒｓ＝－０．５６１，Ｐ＜０．０１）。２６例癌组织中均无ＳＰＣ；癌旁粘膜中ＳＰＣ多位于腺颈及腺底；距肿瘤越近，数量越多。作者认为：癌及ＣＡＭ中ＳＳ水平与细胞分化密切相关，并可能互为影响。ＣＡＭ中ＳＳ水平增高可能是机体籍以迟滞癌生长的一种防御反应。
In a series of 26 cases of colorectal adenocarcinoma, the
somatostatin(SS)levels in thehomogenates of tumors and their surrounding mucosae were
determined by RIA, and the SSpositive cells (SPC)in these tissues were observed by
immunocytochemistry. The resultsshowed: the mean SS level in the cancer-distant mucosae
(CDM,5～10cm away from tumor)was very significantly lower than that in the cancer-adjacent
mucosae(CAM, < 2cm apart)and higher than that in the tumors(P< 0.01). The mean SS levels
both in the welldifferentiated (papillary and grade 1 tubular)adenocarcinomas and in the
mucinousadenocarcinomas were significantly higher than those in moderately differentiated
(grade 2tubular)(<0.0l and 0.05, respectively)and poorly differentiated (grade 3
tubular)tumors(P<0.05). Excepting the mucinous adenocarcinoma, the better the tumor cells
differentiated,the higher the SS level was in the tumor(rs=0.463, P< 0.05). The mean SS Ievel in
CAMswithout dysplasia was very significantly higher than that in such mucosae with different
grades of dysplasia(P<0.0. In CAMs, there was a very significant negative correlationbetween
the SS level and cell dysplasia(rs=0.561, P< 0.01). None of the 26 tumors had SPC.In the
surrounding mucosae, most of SPCs were located in the neck and bottom of glanduloustubules.
The farther the distance the from the tumord was,the 1ess the SPCs were found in the
mucose. The authors considered: In colorectal cancers and their CAMs, SS Ievels are
closelyrelated to cell differentiation and affect each other. The increase in SS level in CAM is
one of the defence reactions of the body for inhibiting the growth of colorectal cancer.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1995年第3期149-152,共4页
Chinese Journal of Digestion
关键词
大肠癌
粘膜
生长抑素
组织匀素
组织匀浆
Carcinoma, colo-rectal
Mucosa
Somatostatin
Tissue homogenate
RIA
Immunocytochemisty.
