摘要
作者用全反式维甲酸（ＡＴＲＡ）治疗５５例急性早幼粒细胞白血病（ＡＰＬ），１４例出现白细胞增多症，发生率为２５．４％，其中外周血白细胞高限在２０×１０￣９／Ｌ～５０×１０￣９／Ｌ之间５例，单用ＡＴＲＡ治疗，４例获完全缓解（８０％）；白细胞高限大于５０×１０￣９／Ｌ９例，采用ＡＴＲＡ与三尖杉酯碱或羟基脲联合化疗，８例获完全缓解（８８．９％）。另外，在９例白细胞高限大于５０×１０￣９／Ｌ的病例中，５例出现白细胞滞留综合征，经治疗后４例滞留症状消失。表明ＡＴＲＡ与化疗相结合，对ＡＴＲＡ治疗期间出现的白细胞增多症是一种有效的措施，可以减低早期死亡率。
ifty-five patients with acute promyelocytic leukemia(APL) were treated with all-trans retinoic acid (A-TRA). Out of these patients , 14 (25. 4%) developedhyperleukocytosis . Five patients with the highestwhite cell counts between 20 ×10￣9/L and 50×10￣9/Lcontinued with only ATRA therapy, and four (80%)obtained complete remission . Nine patients with thehighest white cell counts> 50 ×10￣9/L were treatedwith harringtonine or hydroxyurea in addition to A-TRA and CR was achieved in eight (88. 9%). Mean-while , five of nine patients with the highest white cellcounts>50×10￣9/L developed leukostasis syndrome ,and the syndrome subsided in four after treatment.The results indicated that ATRA/cytotoxic drug com-bination therapy seemed to be an effective modality forthe treatment of hyperleukocytosis during ATRA ther-apy for APL.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1995年第7期341-343,共3页
Chinese Journal of Hematology
关键词
急性
早幼粒细胞
白血病
维甲酸
白细胞增多
Acute promyelocytic leukemia All-trans retinoic acid Hyperleukocy-tosis
