摘要
本实验通过同种异体大鼠肝细胞肾脏内移植，尝试在受体体内建立第二肝脏。对移植肝细胞进行长期组织形态与功能观察，并利用该方法进行急性肝功能衰竭肝功能辅助支持治疗研究。结果表明肝细胞肾脏内移植后可长期存活、增殖而且具有肝组织结构重建及保持肝脏功能的能力。４×１０７个肝细胞肾脏内移植后可显著提高受体大鼠对肝功能衰竭的承受力，移植组术后３天行９０％肝切除诱发急性外科型肝功能衰竭后其存活率显著高于对照组。以上结果显示肾脏可以成为肝细胞移植又一适宜部位，肝细胞肾脏内移植有可能成为临床上肝脏代谢及功能障碍疾病的一种治疗手段。
It was attempted to estiblish an 'ectopic liver' in the recipient by transplanting hepatocytes into the kidney in rats. Long-term morphology and functions of the intrarenal transplanted hepatocytes were observed, and the efficacy of this treatment for surgically induced acute hepatic failure was studied. The results showed that the syngeneic hepatocytes could survive in the kidney cortex at least 10 months after transplantation. The transplanted hepatocytes could proliferate and reconfigurate, and could maintain some hepatic function. The surgically induced acute liver failure by 90% hepatectomy was successfully treated by transplanting 4×107 hepatocytes into kidney in 66.7% of the rats. No animal survived however, in the control group.The results suggest that the kidney could become another suitable site for hepatocyte transplantation. Hepatocyte transplantation into kidney may become a potential clinic application for the case with impaired liver function
出处
《中华器官移植杂志》
CAS
CSCD
1995年第2期72-74,共3页
Chinese Journal of Organ Transplantation
关键词
肝细胞移植
肝功能衰竭
肾脏
Hepatocyte Transplantation Hepatic insufficiency Kidney
