摘要
用Ｐ５３和Ｒｂ，通过免疫金－银染色方法，对３０例前列腺癌及２０例前列腺增生症进行检测。结果显示：前列腺癌Ｐ５３、Ｒｂｃ１５的阳性率分别为６０．０％和５０％，前列腺增生症仅有１０％和１５％，二者之间有显著性差异。前列腺正常组织阳性率Ｐ５３和Ｒｂ为０，与肿瘤区比较Ｐ＜０．００１；３０例前列腺癌中，有１０例Ｐ５３和Ｒｂ同为阳性，Ｐ５３在低分化和未分化癌中阳性表达明显高于高分化腺癌（Ｐ＜０．０１）
cases of carcinoma and 20 cases of hyperplasia of prostate were examined to observe the expression of P53 and RB C-15 anti-oncogene with immunogold silver staining technique,The positive expressions of P53 and RB were 77.77% and 50%respectively for prostatic cancer and were l0%and l5%respectively for hyperplastic prostate.There was neither P53 nor RB expression In the normal prostate region.A significant difference of these expressions between prostatic cancer and hyperplastic prostate(P<0.001)was noted.in addition,of these 30 cases,10 yielded positive expression for both P53 and RB anti-oncogene.P53 and RB positive expressions were obviously stronger in poorly differentiated and undifferentiated carcinoma than in highly differentiated adenocarcinoma.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1995年第7期418-420,共3页
Chinese Journal of Urology
关键词
前列腺肿瘤
癌
基因
病理
Prostate neoplasms Carcinoma Genes
