摘要
１２只成年杂种犬，观察了０．５、１．５ＭＡＣ七氟醚对颅内压的影响。七氟醚吸入顺序Ａ组：０．５→１．５ ＭＡＣ，Ｂ组：１．５→０．５ ＭＡＣ。结果表明：Ａ组吸入０．５ＭＡＣ七氟醚（呼末浓度）５、１５、３０分钟颅内压分别上升２８％、１６％、１５％（Ｐ＜０．０１），吸入１．５ＭＡＣ时分别上升３７％（Ｐ＜０．０１）、１１％、１１％；Ｂ组吸入１．５ＭＡＣ时颅内压分别上升４９％、３１％、２３％（Ｐ＜０．０１），吸入０．５ ＭＡＣ时其接近基础值；与正常ＰａＣＯ２相比，吸入 ０．５ＭＡＣ七氟醚，过度通气后颅内压下降 １３％（Ｐ＝０．０５４），吸入１．５ＭＡＣ时颅内压无显著性变化。结果提示：七氟醚对颅内压影响轻微；低吸入浓度保留了脑血管对ＣＯ２的反应性．高吸入浓度可能抑制脑血管对ＣＯ２反应性。
In order to assess the effects of 0. 5 and 1. 5 MAC of sevoflurane (Sevo ) on Intracranial Pressure (ICP),twelve dogs were randomly (livided Into group Ⅰ (n= 6 ) and group Ⅱ (n= 6). The 0. 5 and 1. 5 MAC of Sevo were inhaled in sequence in group 1 and in reverse order in group i. The end-tidal concentrations of Sevo and carbon dioxide were determined with an infrared analyzer. Cercbrosplnal fluid pressure (CSFP),acting as the parameter for ICP, was recored during normocapnia or hypocapnia, before administration (AD) of Sevo. 5, 15 and 30 mins following AD of Sevo at both concentrations .respectively. During normocapnia. ICP In group Ⅰ increased markedly with 0. 5 MAC of Sevo,and remained statistically unchanged (P>0. 05) following AD of 1. 5 MAC of Sevo,except for the increase at 5th min (P<0. 05 ),and ICP in group Ⅱ rose significantly with 1. 5 MAC of Sevo (P<0. 05 ) and kept stable with 0. 5 MAC of Sevo (P>0. 05 ). As compared with those during normocapnia,ICP decreased by 13 % with 0' 5 MAC o f Sevo,and did not change remarkblely with 1. 5 MAC of Sevo during hypocapnla. It is suggested that 0. 5 and 1. 5 MAC of Sevo produce the slight increase of ICP;cerebral vascular response to CO2 may remains normal during Inhalation of 0. 5 MAC of Sevo, but may be inhibilcd as level of Sevo is ascended to 1. 5 MAC.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1995年第12期553-555,共3页
Chinese Journal of Anesthesiology
关键词
七氟醚
颅内压
过度通气
血液动力学
Sevoflurane Hemodynamics intracranial pressure Hypocapnia
