摘要
目的:观察苦参碱注射液对原发性肝癌肝动脉栓塞化疗后护肝的治疗效果。方法:将我院1999年10月至2004年6月住院的122例接受肝动脉栓塞化疗(TAE)的原发性肝癌患者随机分为两组,治疗组62例,对照组60例,治疗组于TAE术后,在对照组保肝治疗方案基础上,给予苦参碱注射液每天150毫克,静脉滴注2周。两组病人于TAE术前、术后第7、第14天,分别检查血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清总胆红素(STB)和血清白蛋白(ALB)的变化。结果:治疗组于TAE术后1周时,ALT、AST较术前明显升高(P<0.01);2周时,与术前对比无显著性差异(P>0.05)。对照组STB、ALT、AST于术后第1周较术前明显增高(P<0.01),其中ALT、AST至第2周尚未降到术前水平。结论:苦参碱注射液用于TAE术后具有保护肝功能,提高病人对TAE的耐受能力等作用,可使下一次TAE手术得以及时进行。
Objective: To study effect of Matrine injection to prevent the liver function of patients with primary hepatic carcinoma(PHC) after trans-artery chemo-embolization. Methods: 122 patients with PHC admitted to our hospital between October 1999 and June 2004 were randomly divided into therapy group(62 cases) and control group(60 cases). In therapy group, the patients after trans-artery chemo-embolization(TAE) were infused 150 mg Matrine injection once a day for two weeks, while we used other same hepatinica on patients in control group. The levels of alamine aminotransferase(ALT), aspartate aminotransferase(AST), serum total bilirubin(STB), Albumin(ALB) were tested before and after one week and two weeks of TAE. Results: In therapy group, the levels of ALT and AST at one week after TAE were much higher than that before TAE (P<0.01) until two weeks later(P>0.05). In control group, the levels of ALT, AST, STB were all elevated at one week(P<0.01), and that of the ALT and AST did not come down to the levels at two weeks before TAE. Conclusions: Matrine injection may be used to protect the liver function for patients with PHC after TAE, to relieve the liver cells damage, and to improve the tolerance of TAE, so as to perform the next TAE in time.
出处
《中药材》
CAS
CSCD
北大核心
2005年第7期637-638,共2页
Journal of Chinese Medicinal Materials
