摘要
目的探讨肺癌脑转移综合治疗的疗效.方法回顾分析了2002年3月～2004年8月228例肺癌脑转移患者经不同方法治疗后的生存期与生存率.结果转移灶手术切除或γ-刀治疗辅以化疗的中位生存期及1、2年的生存率明显高于单纯γ-刀与化疗组(p＜0.01),肺癌的病理类型对生存期与生存率无明显影响(p＞0.05);单发转移及无颅外转移者生存期(中位生存期分别为9.5和9.5个月)与生存率(1年生存率分别为36%和32%,2年生存率分别为11%和9%)明显高于多发转移及伴颅外血行转移者(p＜0.01).结论转移灶的手术切除或γ-刀治疗辅以化疗是治疗肺癌脑转移患者理想的方法,转移的数量与部位多少是影响预后的因素.
Objective To evaluate the efficacy of comprehensive therapy for lung cancer patient with brain metastasis.Methods The survival time and survival rates with various therapeutic methods were analyzed retrospectively in 228 patients with brain metastasis.Results The median survival time and 1-year and 2-year survival rates in surgery or γ-knife plus chemotherapy group were significantly longer than γ knife-chemotherapy alone (p<0.01). The pathological type of lung cancer did not affect the survival time and survival rate (p>0.05). The survival time and survival rate of single brain metastasis (median survival time was 9.5 months 1, 2 year survival rates were 36% and 11% respectively) and non-extrabrain metastasis (9.5months, 32%, 9%) were much longer than multiple brain metastasis and extrabrain metastasis (p<0.01).Conclusion The comprehensive therapy of surgery or γ-knife plus chemotherapy is better than γ-knife-chemothherapy alone for brain metastasis of lung cancer. The severity of metastasis is the prognostic factor.
出处
《临床肺科杂志》
2005年第5期622-623,共2页
Journal of Clinical Pulmonary Medicine
