摘要
目的比较2004年我科住院的COPD急性发作期痰菌普通培养阴性的患者较常用的几种抗感染治疗的临床疗效及不利因素。方法根据85例次痰菌普通培养阴性的COPD急性发作期的住院病人较常使用的抗感染方法不同分为:A组左氧氟沙星;B组左氧氟沙星和阿莫西林/克拉维酸(阿:克是5∶1)*;C组左氧氟沙星和丁胺卡那;D组阿莫西林/克拉维酸。比较其在控制COPD急性发作所需的住院日,然后进行统计分析。结果各组之间P>0.05,所需的住院日无明显差异。结论左氧氟沙星、阿莫西林/克拉维酸都是广谱抗菌素,对COPD急性发作的常见致病菌均有效,某些联合用药并不能减少控制疾病所需的时间并可增加患者的经济及可能的副作用。
Objective To compare the efficacy and possible unfavorable factors of some anti-infective thesapies to in-patients in our respiratory deparement in 2004 who suffered from the chronic obstructive pulmonary disease (COPD) at acute stage with negative sputum bacterial culture.Methods Eighty-five cases of COPD at acute stage with negative sputum culture were divided into 4 groups, according to types of anti-infective therapies: Group A was given Levofloxacin, Group B was given Levofloxacin and Amoxycillin/Clavulanic acid, Group C was given levofloxacin and Amikacin, Group D was given Amoxycillin/Clavulanic acid. The hospital-stay days for controlling the COPD were compared among the 4 groups. The data were analyzed statistically.Results There was no significant defference among the 4 groups on the hospital-stay days for controlling the COPD (P>0.05).Conclusion Levofloxacin and Amoxycillin/Clavulanic acid are broad spectrum anti-bacterial drugs, both of them are effective to the common bacteria for the COPD patients at acute stage. Some combinations of anti-bacterial drugs can't shorten the treatment period for the COPD at acute stage, and will increase the patients' drugs cost and could present adverse reactions.
出处
《临床肺科杂志》
2005年第5期584-585,共2页
Journal of Clinical Pulmonary Medicine
