摘要
应用放射免疫测定法（ＲＩＡ）和酶联免疫吸附实验（ＥＬＩＳＡ）检测８０例分娩前和分娩后６天，母亲血清及新生儿出生时脐血清，新生儿生后３天、６天血清中分泌型免疫球蛋白Ａ（ＳＩｇＡ）、ＩｇＡ、ＩｇＧ、ＩｇＭ和可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）水平。分为纯母乳喂养组（３０例），混和喂养组（３０例）和人工喂养组（２０例）。结果：３组母亲分娩前后血清中ＳＩｇＡ、ＩｓＡ、ＩｇＧ、ＩｇＭ、ｓＩＬ－２Ｒ水平，差异均无显著性；生后６天新生儿血清与出生时脐血清中ＳＩｇＡ、ＩｇＡ、ＩｇＭ、ｓＩＬ－２Ｒ水平相比，纯母乳喂养组明显高于人工喂养组。提示：纯母乳喂养可以提高新生儿体液免疫和细胞免疫功能。
bjective To determine 4 immunoglobulins and soluble interleukin-2 receptor(sIL-2R ) in mater-nal and neonatal serum, in order to study the immunological functions in the neonates.Methods 80 cases were divided into three groups:(1) breast feeding group(30 cases),(2)for-mula feeding group (20 cses),and(3) mixed feeding group(30 cases).Maternal serum was collected prior to deliverv and on the sixth dav after delivery,Neonatal serum was collected on the third and sixth day after delivery。Umbilical blood at birth was obtained also,Secretory immunoglobulin A(SIgA),IgA,IgG,IgM and slL-2R levels in the sera were determined by radioimmunoassay and enzyme-linked immunosorbent assay. Resul ts The SIgA,IgA,IgG,IgM and sIL-2R levles in maternal serurn were not significantly different among 3 groups, , while neonatal serum SIgA ,IgA,IgG, IgM and sIL- 2R levels on the sixth day after delivery in the breast feeding group were significantly higher than those in the formula breed-ing group(P<0. 001, P<0. 001,P<0. 05, P<0. 05)。Conclusion Breast feeding may improve neonatal humoral and cellular immunity.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1995年第10期584-587,共4页
Chinese Journal of Obstetrics and Gynecology
