摘要
应用酶联免疫方法对正常未孕妇女２８例、不同孕周的正常孕妇１０１例（包括产后）及妊高征患者２５例尿中各种蛋白进行检测。结果：孕妇在妊娠早期尿中白蛋白及ＩｇＭ排出较非孕妇女明显增多（Ｐ＜０．０５～０．０１），ＩｇＧ亦有增多趋势。妊高征患者与正常不同孕周的孕妇相比，ＩｇＧ、ＩｇＡ、白蛋白的排出均明显增加（Ｐ＜０．０５～０．０１），而ＩｇＭ无差异；产后与孕晚期妇女相比，ＩｇｓＭ明显减少（Ｐ＜０．０５）；正常不同孕周的孕妇尿中各项蛋白的排出，虽随孕周的增加而增多，但无统计学差异。妊高征患者尿中白蛋白的排出与病情严重程度有关，其中妊高征患者的平均动脉压（ＭＡＰ）与尿中白蛋白、ＩｇＧ的排出呈正相关。
bjective To study the excretion of urinary proteins in women at different periods of pregnancy and women with pregnancy induced hypertension。Methods Urinary proteins(albumin,lgA,IgG.IgM)were measured at random with enzyme- linked immunosorbent assay (ELISA ) in 101 normal pregnant women,25 women with pregnancy in- duced hypertension and 28 nonpregnant women。Results Urinary albumin and IgM levels in women of early pregnancy were significantly higher than thase in nonpregnant women(P<0.05～0.01).Urinary IgG level was alsO increased during pregnan cy.Urinary excretion of albumin,IgA,and IgG,but not IgM excretion was significantly elevated in women wtth pregnancy induced hyperiension compared to normal pregnant women at different gesta- tional ages(P<0. 05～0.01).Urinary IgM level in postparium period was significantly lower than that in late pregnancy(P<0.05 ).Urinary protein excretion increased with gustational age during normalpregnancy,but the changes were not statistically significant.However,he protein excretion was associ- ated with severity of the diseases。Urinary ablumin and IgG excretions in hypertensive pregnant women were correlated positively with mean arterial blood pressure。Conclusions The change in glomerular filtration in pregnant women with mild to mederate hyper- tension is reversible. It is imporiant to control bled perssure to avoid impairment of kidney function in pregnancy induced hypertension.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1995年第7期395-397,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
妊娠
蛋白尿
妊娠高血压
综合征
Preghancy Urinary protein Pregnancy induced hypertension
