摘要
通过对３２例喉癌患者围手术期血清ｓＩＬ－２Ｒ与急性期蛋白（α１—ＡＴ、α１—ＡＧ、ＨＰ）的检测，发现喉癌患者围手术期血清ｓＩＬ－２Ｒ与急性期蛋白明显高于正常人，且二者有正相关性（Ｐ＜０．０１）。在喉癌患者中，声门上型和混合型喉癌的上述指标水平高于声门型喉癌（Ｐ＜０．０１），临床Ⅲ、Ⅳ期喉癌患者血清中ｓＩＬ－２Ｒ与急性期蛋白水平高于Ⅰ、Ⅱ期患者（Ｐ＜０．０５及Ｐ＜０．０１），手术后短期内ｓＩＬ－２Ｒ水平升高。因此，ｓＩＬ－２Ｒ与急性期蛋白联合检测，对喉癌的临床分型、分期、疗效评价及预后监测均具有指导意义，且具有简便、快速、无创伤等优点，可广泛应用于临床。
Serum levels of soluble interleukin 2 receptor(sIL-2R)and acute phase protein(α1-AT,α1-AG,HP)were measured during the peioperative period in 32 patients with laryngeal carcinoma.The results indicated that the serum levels of sIL-2R and acute phase protein were significantly higher in patients with laryngeal cancer than those in normal control group.Proportionate correlation was found between the levels of sIL-2R and acute phase protein.In patients with laryngeal carcinoma,the levels of serum sIL-2R and acute phase protein were significantly higher in the supraglottis tumors than that in the glottis tumor(P<0.01).They were significantly higher in the tumors of clinical Ⅲ, Ⅳ stage disease than those in patients with clinical Ⅰ,Ⅱstage disease.The levels of serum sIL-ZR were elevated shortly after operation.It Is suggested that combined evaluation of serum sIL-2R and acute phase protein may be useful in the clinical localization and staging,and it is easy and quick to perform and harmless.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1995年第6期417-420,共4页
Chinese Journal of Clinical Oncology
关键词
白细胞介素2
受体
急性期
蛋白
喉肿瘤
血清
Laryngeal carcinoma
Soluble interleukin-2 receptor(sIL-2R)
Acute phase protein
