摘要
用碘标记抗胃癌单克隆抗体（（１３１）Ｉ－３Ｈ（１１））对１４例胃癌患者进行放射免疫导向手术中的药代动力学研究。静脉给药组（ＩＶ）（ｎ＝７）和胃镜粘膜下给药组（Ｅｎｄｏ）（ｎ＝７）其动力学模型经微机拟合均为两室模型。Ｔ１／２β分别为２２．６５±１．３８（ＩＶ）和２１．０２±２．１８（Ｅｎｄｏ），统计学差异不显著。两种给药方式消除规律相似，ＩＶ组并不比Ｅｎｄｏ组清除快。
The pharmacokinetics of radioiodinated murine anti-human gastric cancer antibody(MAb 3H(11))radioimmunoguided surgery in 14 patients with gastric cancer was evaluated with isotopic tracing. The microcomputer graphic portrayal conform to a two-compartment model for both intravenous administration (IV)(n=7)and submucous membrane injection at endoscopic Samples(Endo)(n=7).The difference of the elimination half-life between the IV group(22. 65±1. 38)and Endo group(21.02±2.18)was not significant(P>0.05). These results indicate that radioiodinated antibody administered via Endo is not cleared more rapidly than intravenous injection.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1995年第5期305-308,共4页
Chinese Journal of Clinical Oncology
关键词
碘标记
胃癌
单克隆抗体
半衰期
药代动力学
Radioiodinate
Murine anti-human gastric cancer antibody
Elimination half-life
Pharmacokinetics
