摘要
本研究旨在证实合用桃仁提取物和虫草菌丝的抗肝纤维化作用,对二者合用对由CCI_4引起的实验性肝纤维化的防治作用进行实验观察,以生理盐水作同期对照。结果表明:HE染色观察合用预防组肝细胞变性较对照组有减轻趋势,治疗组肝细胞仅见少数变性,部分病例恢复正常结构;预防组纤维组织增生较对照组有减轻趋势,治疗组纤维间隔少而薄,与对照组比较(P<0.05);电镜观察预防组肝细胞变性较对照组轻,细胞间隙正常,治疗组少量肝细胞变性,肝窦充盈及枯否氏细胞增生明显;肝羟脯氨酸与肝胶原酶活性较对照组明显改善。由此提示二药具有明确的抑制肝内胶原蛋白沉积和纤维组织增生以及促进纤维化肝脏结缔组织降解作用,其机制除保护肝细胞外,主要与激活胶原酶有关。
In order to prove the anti-hepatic fibrosis effects of peach seed extract and cordyceps,we observed the prevention and cure of these two herbs on laboratory heptic fibrosis. The results showed that the degeneration of liver cells in prevention group was abatement?these was small number of liver cells to get degener-taion in cure group. The proliferation of hepatic fibrous tissue in erevention group got better than that of controlled group > the fibrous septum in cure group was small amount and thin. All these suggested that combination of peach seed extract and cordyceps could control the sedimentation of collage in liver and the fibrous septum and promote the degratation of connective tissue.
The mechanism related to activate collagenase except for prelecting liver-cells.
出处
《中国中医药科技》
CAS
1995年第1期18-20,共3页
Chinese Journal of Traditional Medical Science and Technology
