摘要
目的分析青中年冠心病患者中代谢综合征(MS)危险因素的分布与聚集状况,为早期防治干预提供依据。方法对103例青中年男性[年龄30～50(43.3±5.7)岁]冠心病患者及64例男性[年龄28～50(42.8±6.3)岁]冠状动脉造影正常的对照组的临床特征和生化特点进行比较。按照中华医学会糖尿病学分会标准诊断MS。结果两组在年龄上无差异。冠心病组的吸烟率显著高于对照组,但在冠心病家族史方面两组无差异。冠心病组的总胆固醇(TC)、餐后2h血糖(2hPBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMAIR)均显著高于对照组,而HDLC显著低于后者。冠心病组MS的发生率显著高于对照组(P<0.01)。Logistic回归分析显示,吸烟、低HDLC、HOMAIR、MS使青中年人冠心病患病的相对危险度增加。结论青中年冠心病患者多种代谢异常更加严重,对于青中年男性应重视MS的预防,以减少心血管事件的发生。
Objective:To study the distribution of metabolic syndrome in young and middle age patients with coronary artery disease. Method:One hundred and three young and middle age men with coronary artery disease(CAD) and 64 cases age matched men were retrospectively studied. All of them underwent selective coronary angiography.Result:As compared with the group of control, patients with CAD showed higher TC, 2 h PBG,FINS,HOMA-IR,and lower HDL-C values. According to CDS standard, they also had high frequencies of metabolic syndrome(MS), accounting for 48.5%. Multiple logistic regression analysis showed that close relationships exist between CAD and smoking ( OR =2.123), lower HDL-C( OR =1.115), HOMA-IR( OR =1.735), MS( OR =2.542). Conclusion:Metabolic syndrome is common in young and middle age patients with CAD. It is necessary to control multiple risk factors in order to prevent cardiovascular event.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2005年第7期387-389,共3页
Journal of Clinical Cardiology
