摘要
分别向杏仁内侧核（ＭＡＮ）内微量注射去甲肾上腺素（ＮＡ）或神经肽Ｙ（ＮＰＹ）。ＮＡ引起血压升高，心率加快；而ＮＰＹ引起血压降低，心率减慢。如果注入不能改变血压的小剂量ＮＰＹ，则可抑制ＮＡ引起的升压作用，反映ＮＰＹ与ＮＡ共同参与心血管活动的中枢性调节过程。向ＭＡＮ中注射ＮＰＹ后血中ＮＡ的含量也相应降低，表明在ＭＡＮ中注射ＮＰＹ引起的血压、心率反应是通过降低血浆中ＮＡ含量而实现的。
Experiments were carried out in Wistar rats. Micro-injection of noradrenaline (NA) intomediai amygadaloid nucleus(MAN)induced the rising of blood pressure and increase in heartrate. Microinjection of neuropeptide Y(NPY)into MAN caused decrease in blood pressure andheart rate. When NPY at a dosage not inducing any change of blood pressure was used before in-jection of NA the pressor effect of NA injected into MAN was inhibited,indicating that NPY andNA had interaction in the central regulation of cardiovascular activities.In the meantime,injec-tion of NPY into MAN also induced decrease in the NA concentration of peripheral blood. Itseems that the cardiovascular effects elicited by injection of NPY into MAN are the results of de-crease in NA in the peripheral blood.
出处
《中国应用生理学杂志》
CSCD
1995年第4期346-349,共4页
Chinese Journal of Applied Physiology
基金
国家自然科学基金资助课题
关键词
杏仁内侧核
神经肽Y
去甲肾上腺素
血压
心率
medial amygdaloid nucleus
noradrenaline
neuropeptide
blood pressure
heart rate
