摘要
目的探讨咪达普利(IMI)对家兔陈旧性心梗(HMI)后心脏有效不应期(ERP)及钠电流(I_(Na))的影响。方法选家兔制 HMI 模型,口服 IMI 0.625mg·kg^(-1)·d^(-1)(8周)。记录整体心脏 ERP 和单细胞 I_(NA)。结果 HMI 组ERP 显著延长,用 IMI 后则缩短。HMI 组代偿区细胞 I_(Na)降低,I_(Na)稳态失活曲线负移,恢复时间常数延长;应用 IMI,I_(Na)明显恢复。结论咪达普利可抑制 HMI 心脏 ERP 延长,并使降 I_(Na)得以恢复。这可能是该药减少陈旧性心梗后心律失常发生的机制之一。
Aim To investigate the effects of imidapril (IMI) on effective refractory period (ERP) and sodium current (I_(Na)) of myocytes in ventricular noninfarction zone of healed myocardial infarction (HMI) in rabbit models.Methods Rabbits with left coronary artery ligation were prepared and IMI (0.625 mg·kg^(-1)·d^(-1),8 weeks) was orally administered.The ERP and sodium current were recorded. Results The ERP in HMI heart was prolonged.The ERP in IMI group was lower significantly than that of HMI group.The I_(Na) density of myocyte in HMI ventricle decreased obviously.V_(1/2) of steady state inactivation of I_(Na) shifted to hyperpolarization,and time constant (τ) of recovery from inactivation in HMI ventricular myocyte was longer than that of sham ventricular myocyte.I_(Na) density in IMI group increased markedly as compared with that of HMI group.Conclusion IMI was shown to reverse the abnormal prolongation of ERP in rabbit heart with the HMI and increase I_(Na) density.It may be the mechanism of IMI preventing against antiarrhythmia in healed myocardical infarction.
出处
《药学学报》
CAS
CSCD
北大核心
2005年第7期654-658,共5页
Acta Pharmaceutica Sinica
关键词
咪达普利
陈旧性心肌梗死
有效不应期
钠电流
imidapril
healed myocardical infarction
effective refractory period
sodium current
