摘要
目的:探讨嗜酸粒细胞阳离子蛋白(ECP)在鼻内镜鼻腔黏膜转归过程中表达变化的规律.方法:采用酶免疫荧光分析技术检测ECP在10例Ⅰ型、Ⅱ型慢性鼻窦炎患者功能性鼻窦开放术后术腔黏膜恢复过程中的表达变化.结果:ECP蛋白在正常鼻黏膜中少量表达,而在慢性鼻窦炎黏膜或息肉中明显升高,且随时间呈现如下变化规律:①术后1～2周较术前明显降低(P<0.01);②术后4～6周达高峰,基本恢复至术前水平;③术后10～12周回落,接近于术后1～2周水平.结论:ECP在术后4～6周表达明显增高,提示其可能参与延迟内镜鼻窦鼻腔黏膜上皮化的进程.
Objective:To study the secretion of ECP during different phrase of transitionary process of mucosa in sinu cavity after endoscopic sinus surgery.Method:Secretion of ECP was determined with enzyme-fluoroimmunoassay method during different phrase of transitionary process of mucosa in sinu cavity in 20 patients with type Ⅰand type Ⅱchronic sinusitis after endoscopic sinus surgery.Result:Comparing the patients in 1~2 week after surgery with the conditions before surgery,a significant decrease of secretion of ECP was found (P<0.01).In 4~6 weeks after surgery, increasing amounts of secretion of ECP were found, nearly reaching the conditions before surgery again.In 10~12 weeks,the secretion of ECP tended to the level as 1~2 week after surgery.Conclusion:This study may indicate that the ECP involvs in the transitionary process of mucosa in sinu cavity after endoscopic sinus surgery.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2005年第14期627-629,共3页
Journal of Clinical Otorhinolaryngology
