摘要
目的:比较各种人工肝支持系统治疗重型肝炎的疗效及其影响因素。方法:对117例患者进行了322例次血浆置换(PE)、243例次血液滤过(HF)、10例次白蛋白吸附转运治疗,伴肾功能衰竭者,加做血液透析(HD)。对症状缓解、肝功能等生化指标、血气分析各种项目进行综合评价,并进行了血浆置换量、血浆置换次数、治疗早晚及联合治疗等影响因素的研究。结果:血浆置换可使患者生化指标改善,血浆置换量3000mL/L为宜,根据不同情况确定治疗频度,HF在纠正酸碱平衡及电解质紊乱方面优于PE,白蛋白吸附对胆红素下降有较明显作用。结论:人工肝支持系统是治疗重型肝炎的有效方法,注意影响疗效的因素,可取得更佳效果。
Objective To compare the efficacy of plasma exchange hemofiltration hemoperfusion absorption in treatment of severe hepatitis and study the influence factors of artificial liver support system ALSS. Methods One hundred and seventeen patients were treated with plasma exchange therapy PE 322 times hemofiltration therapy HF 243 times and hemoperfusion absorption therapy 10 times. For those with renal failure hemodialysis therapy HD would be added in treatment. The clinical symptoms liver function and arterial blood gas measurements were evaluated synthetically. Plasma quantity numbers of plasma exchange starting time of treatment and joint treatment were analyzed. Results Plasma exchange could obviously improve the biochemical index with 3 000 mL/L of the plasma quantity. The frequency of PE was decided by according to patient’s condition. HF was superior to PE in treating acid-alkaline imbalance and electrolyte mess. Albumin absorption could lower the bilirubin level. Conclusion ALSS was effective in treating severe hepatitis. It would be better by paying attention to the influence factors.
出处
《天津医药》
CAS
北大核心
2005年第7期416-418,共3页
Tianjin Medical Journal
