摘要
目的探讨β-catenin和COX-2在大肠癌中的表达及临床意义。方法采用免疫组化技术检测153例大肠组织标本中β-catenin和COX-2的表达水平,并对其临床意义和相互关系进行统计学分析。结果β-catenin在细胞膜上的丢失与腺癌的分化程度、Dukes分期及淋巴结转移具有相关性(P<0.05);COX-2的过表达与腺癌的Dukes分期、淋巴结转移和浸润程度具有相关性(P<0.05);β-catenin的异位表达与COX-2的过表达没有相关性。结论细胞膜上β-catenin的表达减少在分化程度低、Dukes分期晚及有淋巴结转移的患者中更明显。COX-2的表达水平在Dukes分期晚、浸润程度及有淋巴结转移的患者中增高更明显。腺癌中β-catenin的异位表达可能不是COX-2过表达的主要原因。β-catenin和COX-2可能是Dukes分期和判断淋巴结转移风险的一个较好的指标。
Objective To investigate the expression and clinical significance of β-catenin and COX-2 in human colorectal carcinoma. Methods [WTBZ]The expression of β-catenin and COX-2 in 153 colorectal tissue specimens was examined by immunohistochemical technique, and their clinical significance and correlation were statistically analyzed. Results In colorectal adenocarcinoma, the loss of β-catenin in the cytomembrane was significantly correlated with the differentiated degree, lymph node metastasis and Dukes' stages, while COX-2 overexpression was associated with the Dukes' stages,lymph node metastasis and infiltrating depth. The ectopic expression of β-catenin was not associated with the COX-2 overexpression. [WTHZ] Conclusion COX-2 and β-catenin may play a role in the pathogenesis of colorectal adenocarcinoma. The ectopic expression of β-catenin may be not the main reason of the COX-2 overexpression in colorectal adenocarcinoma. Detection of β-catenin and COX-2 expression may be helpful for Dukes' staging and evaluating the risk of lymph node metastasis in colorectal adenocarcinoma.
出处
《中国医师杂志》
CAS
2005年第7期889-891,共3页
Journal of Chinese Physician
关键词
Β-CATENIN
COX-2
大肠癌
表达
免疫组化
Colorectal neoplasms/pathology
β-catenin
Cyclooxygenase-2
Wnt signal pathway
Immunohistochemistry
