摘要
目的对比奎的平与氯氮平治疗复发性精神分裂症的疗效和安全性。方法分别以奎的平与氯氮平治疗复发性精神分裂症36例,采用阳性症状与阴性症状量表(PANSS)、副反应量表(TESS)在治疗前及治疗后第1、2、4、6、8周末分别评定疗效及不良反应。结果奎的平有效率77.8%,显效率61.1%;氯氮平有效率75%,显效率58.3%,两药的疗效相当;两组治疗后与治疗前的PANSS评分比较差异均有显著性,奎的平不良反应少于氯氮平。结论奎的平治疗复发性精神分裂症疗效较好,不良反应较氯氮平轻,病人服药依从性好。
Objective To compare the efficacy and safety between quetiapine and clozapine in the treatment of recurrent schizophrenia. Methods Thirty-six recurrent schizophrenic patients were treated with quetiapine and thirty-six patients with clozapine.The efficacy was assessed with the Positive And Negative Symptoms Scale(PANSS),and the side effects with the Treatment Emergent Symptom Scale(TESS).Results The effective rate and marked improvement rate in quetiapine were 77.8% and 61.1%,and these rates in clozapine were 75% and 59%.There were no differences between two groups.The PANSS scores in both groups decreased significantly after treatment.Quetiapine had fewer side effects than clozapine.Conclusion Quetiapine has good efficacy,high safety,few side effects and good compliance in treating schizophrenia.
出处
《山东精神医学》
2005年第3期167-168,共2页
Shangdong Archives of Psychiatry
