摘要
为了对Huntington舞蹈症进行早期准确的基因诊断,作者应用聚合酶链反应直接检测IT15基因CAG三核苷酸重复序列,对武汉某Huntington舞蹈症(HD)家系两代11名家庭成员进行了基因诊断。PCR产物的取丙烯酰胺凝胶电脉结果显示5例HD高风险者有4例携带异常HD基因。
Using the technology of polymerase chain reaction and polyacrylamide gel electrophoresis,we examine the number of CAG Triplets in IT15 gene directly,then we can give an early and exact gene diagnosis for Huntington disease.We examined 11 persons who come from a HD family. The result shows that 4 of total 5 high risk members carry the HD gene.
出处
《中国优生与遗传杂志》
2005年第7期25-27,共3页
Chinese Journal of Birth Health & Heredity
