摘要
目的:探讨肺炎衣原体(Cpn)与冠状动脉粥样硬化心脏病(CHD)之间的相互关系。方法:采用PCR和ELISA ,分别对2 0 0例经冠状动脉造影证实的冠心病患者和非冠心病对照组进行全血标本肺炎衣原体DNA和血清中抗肺炎衣原体IgG检测。结果:冠心病组肺炎衣原体DNA阳性率为4 3 4 0 % ,对照组阳性率为7 32 %。冠心病组肺炎衣原体IgG抗体阳性率为6 4 78% ,对照组阳性率为31 71%。两组肺炎衣原体DNA和IgG抗体阳性率差异均有显著性(P <0 0 1)。
Objective:To understand the state of Chlamydia pneumoniae (Cpn) infection in patients with coronary hear disease (CHD), and explore the relationship between Cpn infection and the gonesis and progressin of CHD.Methods:By means of PCR and ELISA, Cpn IgG antibody and nucleic acid were detected in 159 patients with CHD and 41 control subjects.Results:The positivity rate of Cpn DNA was 43 40%(69/159) in the patient group and 7 32%(3/41) in the control group, showing obvious difference between the two groups( P <0 01). The positivity rate of serum Cpn IgG antibodies was 65 41%(104/159) in the CHD group and 31 71%(13/41) in the control group, showing significant difference ( P <0 01).Conclusion:Cpn infection is closely connected with the CHD.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2005年第5期400-402,共3页
Chinese Journal of Immunology
基金
广东省科技攻关资助项目 ( 99M0 460 8G)
关键词
肺炎衣原体
冠心病
核酸
抗体
Coronary heart disease
Chlamydia pneumoniae
Nucleic acid
Antibody
