摘要
目的:为了探讨腹腔镜子宫肌瘤剔除术对Th1/Th2细胞平衡的影响。方法:择期子宫肌瘤患者4 0例,分别采用腹腔镜手术和常规开腹手术,测定术前、术后2、2 4、4 8小时Th1、Th2细胞数量及血清IL 18、IL 10水平。结果:两组术后2小时均出现Th1/Th2细胞平衡向Th2反应转换,Th1细胞、Th1/Th2比值、IL 18下降(腹腔镜组:P <0 0 5 ,P <0 0 1,P <0 0 5 ;开腹组:P <0 0 1,P <0 0 1,P <0 0 1) ,而Th2细胞、抗炎因子IL 10上升(腹腔镜组:P <0 0 1,P <0 0 1;开腹组:P <0 0 1,P <0 0 1)。但腹腔镜组术后2 4小时各项指标即恢复,而开腹组各项指标的变化与术后2小时类似,并持续至术后4 8小时。结论:腹腔镜子宫肌瘤剔除术对Th1/Th2细胞平衡影响小,恢复快,优于开腹手术。
Objective:To investigate the influences of laparoscopic surgery on Th1/Th2 balance in patients with uterine myomas.Methods:In a prospective study,the number of the Th subsets,Th1/Th2 ratio,the serum level of IL-18 and IL-10 in 20 patients submitted to laparoscopic operation and 20 patients undergoing conventional open operation were evaluated preoperatively as well as 2,24,48 h postoperatively.Results:The level of Th1 cell,IL-18,and the Th1/Th2 ratio decreased significantly (laparoscopic group: P <0 05, P <0 01, P <0 05;open group: P <0 01, P <0 01, P <0 01),while Th2 cell,IL-10 rose significantly (laparoscopic group: P <0 01, P <0 01;open group: P <0 01, P <0 01) 2 h postoperatively in both groups.The indexes of laparoscopic surgery group resumed to the preoperative levels 24 h postoperation,but the changes sustained in open surgery group till 48 h postoperatively.Conclusion:Laparoscopic surgery had fewer influences on Th1/Th2 balance postoperatively.Laparoscopic surgery was more advantageous than open surgery.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2005年第5期390-392,共3页
Chinese Journal of Immunology
