摘要
目的探讨阿尔茨海默病(Alzheimerdisease,AD)患者血清白细胞介素10(interleukin10,IL10)、可溶性白细胞介素6受体(solubleinterleukin6receptor,sIL6R)水平变化及其与痴呆严重程度的关系。方法采用双抗体夹心ELISA法检测46例AD患者(AD组)、33名年龄匹配健康者(对照组)和40例脑梗死患者(CI组)血清IL10、sIL6R水平。结果AD患者血清IL10水平较正常对照组和CI组均明显降低,但对照组与CI组间差异无显著性。AD患者血清sIL6R水平较正常对照组明显升高并随痴呆程度加重而不断上升;CI组中血清sIL6R水平也明显高于对照组,但AD组和CI组间差异无显著性。结论AD患者血清IL10和sIL6R水平的变化提示免疫炎性机制参与了AD的发病。
Objective To investigate the level of interleukin-10 (IL-10) and soluble interleukin-6 receptor(sIL-6R) in serum of patients with Alzheimer disease (AD) and its correlation with severity of AD. Methods The concentrations of serum IL-10 and sIL-6R were measured by means of an enzyme-linked immunosorbent assay in 46 AD patients, 40 cerebral infarction (CI) patients and 33 healthy control subjects. Results The level of IL-10 was significantly decreased in AD patients, compared with both CI patients and healthy control subjects, but did not differ between CI patients and healthy control subjects. sIL-6R content was significantly increased in AD (patients,) especially in the severe AD patients, No statistical difference in the concentration of sIL-6R was noted between AD patients and CI patients. Conclusions Alteration of serum IL-10 and sIL-6R levels are found in AD patients, demonstrating that inflammation is involved in the pathological process of AD.
出处
《中国神经免疫学和神经病学杂志》
CAS
2005年第4期216-218,246,共4页
Chinese Journal of Neuroimmunology and Neurology
