M受体亚型在切口痛大鼠鞘内注射新斯的明超前镇痛中的作用
被引量:1
摘要
鞘内注射胆碱酯酶抑制剂新斯的明(NEO)能以剂量依赖性方式产生明显的抗伤害作用和超前镇痛作用[1-4],其确切的作用机制仍不十分清楚.这种抗伤害作用主要与毒蕈碱(M)受体兴奋有关[5],但是与何种受体亚型有关尚无定论.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2005年第5期377-378,共2页
Chinese Journal of Anesthesiology
基金
江苏省省级高校重点实验室开放课题(KJS1085)
参考文献14
-
1Hwang JH, Hwang KS, Lee JK, et al. The antiallodynic effects of intrathecal cholinesterase inhibitors in a model of neurophathic pain.Anesthesiology, 1999, 90: 492-499. 被引量:1
-
2胡兴国,杨亚夫,张云翔,钟敏,曾因明,段世明,潘道波.在大鼠切口疼痛模型中鞘内新斯的明对脊髓NO/cGMP信号转导系统的影响[J].中华麻醉学杂志,2001,21(4):229-232. 被引量:6
-
3Grant GJ, Piakoun B, Bansinath M. Intrathecal administration of liposomal neostigmine prolongs analgesia in mice. Acta Anaesthesiol Scand,2002, 46: 90-94. 被引量:1
-
4Tan PH, Chia YY, Lo Y, et al. Intrathecal bupivacaine with morphine or neostigmine for postoperative analgesia after total knee replacement surgery. Can J Anaesth, 2001, 48: 551-556. 被引量:1
-
5胡兴国,张云翔,段世明,曾因明.脊髓毒蕈碱受体与镇痛[J].国外医学(麻醉学与复苏分册),2001,22(5):309-311. 被引量:4
-
6Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav, 1976, 17: 1031-1036. 被引量:1
-
7Brennan TJ, Vandermeulen EP, Gebhart GF. Characterization of a rat model of incisional pain. Pain,1996, 64: 493-501. 被引量:1
-
8Chaplan SR, Bach FW, Pogrel JW, et al. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Meth, 1994, 53: 55-63. 被引量:1
-
9Naguib M, Yaksh T. Characterization of muscarinic receptor subtypes that mediate antinociception in the rat spinal cord. Anesth Analg, 1997, 85:847-853. 被引量:1
-
10Yoon MH, Choi JI, Jeong SW. Antinociception of intrathecal cholinesterase inhibitors and cholinergic receptors in rats, Acta Anaesthesiol Scand, 2003, 47: 1079-1084. 被引量:1
二级参考文献11
-
1胡兴国.-[J].中华麻醉学杂志,2001,21:229-229. 被引量:1
-
2Hwang JH,Hwang KS,Leem JK,et al.The antiallodynic effects of intrathecal cholinesterase inhibitors in a rat model of neurophathic pain[].Anesthesiology.1999 被引量:1
-
3Lauretti GR,Reis MP,Prado WA,et al.Dose-response study of intrathecal morphine versus intrathecal neostigmine, their combination, or placebo for postoperative analgesia in patients undergoing anterior and posterior vaginoplasty[].Anesthesia and Analgesia.1996 被引量:1
-
4Yaksh TL.Spinal systems and processing: development of novel analgesic drugs with mechanistically defined models[].TIPS.1999 被引量:1
-
5Sluka KA,Willis WD.The effects of G-protein and protein kinase inhibitors on the behavioral response of rats to intradermal injection of capsaicin[].Pain.1997 被引量:1
-
6Kawamata T,Omote K.Activation of spinal N-methyl-D-aspartate receptors stimulates a nitric oxide/cyclic guanosine 3’, 5’monophosphate/glutamate release cascade in nociceptive signaling[].Anesthesiology.1999 被引量:1
-
7Naguib M,Yaksh TL.Characterization of muscarinic receptor subtypes that mediate antinociception in the rat spinal cord[].Anesthesia and Analgesia.1997 被引量:1
-
8Pavone F,Capone F,Populin R,et al.Nitric oxide synthase inhibitors enhance the antinociceptive effects of oxotremonine in mice[].Polish Journal of Pharmacology.1997 被引量:1
-
9Brennan TJ,Umali EF,Zahn PK.Comparison of pre versus postincision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative pain[].Anesthesiology.1997 被引量:1
-
10Brennan TJ,Vandermeulen EP,Gebhart GF.Characterization of a rat model of incisional pain[].Pain.1996 被引量:1
共引文献8
-
1耿洪涛,吴丽娜.单次硬膜外推注给药与PCEA镇痛效果的比较[J].内蒙古医学杂志,2004,36(9):672-673.
-
2庞洪生,李越.地塞米松对吗啡硬膜外镇痛不良反应的影响[J].上海医学,2005,28(11):976-977. 被引量:2
-
3石峻林.布比卡因用于硬膜外麻醉术后镇痛(附272例报告)[J].医学信息(手术学分册),2007,20(8):716-717.
-
4张颜波,吕国蔚.PKC抑制剂灯盏花素乙对内脏炎症痛大鼠脊髓NO/cGMP信号转导系统的影响[J].中国药理学通报,2007,23(12):1601-1604. 被引量:7
-
5孔晓东,张鑫,杨金兰,吕凯.地塞米松减少吗啡硬膜外镇痛副作用的观察[J].中国实用医药,2011,6(17):161-162.
-
6陆惠元,于礼,冷翠波,王寿世,曲雪红,戴晓凤,于建志.利多卡因与丁哌卡因复合新斯的明硬膜外术后镇痛的比较[J].中国临床研究,2013,26(8):818-819. 被引量:2
-
7关景芳,聂卫,王理,刘爱恒.利多卡因对致痛大鼠L_(4~5)脊髓P物质分布影响的实验研究[J].河北医药,2003,25(9):643-644. 被引量:2
-
8刘志芳,戴红,高秀来,肖忠新,景鹏.脊髓损伤后慢性中枢性疼痛与脊髓背角P物质关系研究[J].中国康复理论与实践,2003,9(12):719-721. 被引量:5
同被引文献9
-
1麻海春,王艳芬,冯春生,曾维安,孙丽华,卢宝顺,赵华.大鼠脑干网状结构胆碱能神经兴奋在疼痛信号传导中的作用[J].中华医学杂志,2005,85(12):852-853. 被引量:4
-
2MAKII A A, BASKIN D G, STAHL W L. [^3H]-ouabain binding sites in rat brain: distribution and properties assessed by quantitative autoradiography [J]. J Histochem Cytochem, 1992, 40(6):771-779. 被引量:1
-
3LOMEO R S, GOMEZ R S, PRADO M A, et al. Exocytotic release of [^3H]-acetylcholine by ouabain involves intracellular Ca^2+ stores in rat brain cortical slices [J]. Cell Mol Neurobiol, 2003, 23(6):917-927. 被引量:1
-
4BOUAZIZ H, TONG C, EISEBACH J C. Postoperative analgesia from intrathecal neostigmine in sheep [J]. Anesth Analg, 1995, 80(6):1140-1144. 被引量:1
-
5ABELSON K S, HOGLUND AU. Intravenously administered oxotremorine and atropine, in doses known to affect pain threshold, affect the intraspinal release of acetylcholine in rats [J]. Pharmacol Toxicol, 2002, 90(4):187-192. 被引量:1
-
6TAN P H, CHIA Y Y, LO Y, et al. Intrathecal bupivacaine with morphine or neostigmine for postoperative analgesia after total knee replacement surgery [J]. Can J Anaesth, 2001, 48: 551-556. 被引量:1
-
7ZENG W, DOHI S, SHIMONAKA H, et al. Spinal antinociceptive action of Na^+-K^+ pump inhibitor ouabain and its interaction with morphine and lidocaine in rats [J]. Anesthesiology, 1999, 90(2):500-508. 被引量:1
-
8CHAPLAN S R, POGREL J W, YAKSH T L. Role of voltage dependent calcium channel sutypes in experimental tactile allodynia [J]. J Pharmacol Exp Ther, 1994,269:1117-1123. 被引量:1
-
9NAGUIB M, YAKSH T L. Characterization of muscarinic receptor subtypes that mediate antinociception in the rat spinal cord [J]. Anesth Analg, 1997, 85(4):847-853. 被引量:1
-
1吴健华,陈志远,王玉珍,曾清峰.长托宁胸外科手术前用药的临床观察[J].福建医药杂志,2008,30(3):68-69. 被引量:1
-
2孙耀飞(综述),方祖军(审校).抗毒蕈碱药物治疗膀胱过度活动症的研究进展[J].国际泌尿系统杂志,2010,30(3):342-345.
-
3王世端,阎伟,江岩,刘英志,周赞宫,程永炜.不同剂量硫酸镁对麻醉诱导期病人异丙酚效应室靶浓度及血液动力学的影响[J].中华麻醉学杂志,2008,28(10):947-948.
-
4张大权,王柏榆,孙大军.长托宁预防老年人腹主动脉转流术后寒战及呕吐7例[J].中国老年学杂志,2012,32(21):4768-4769.
-
5吕克重,王玉英,李铁成,李德生,谷淼,汪向东.长托宁麻醉前用药对患者心率的影响[J].中国误诊学杂志,2006,6(10):1856-1857. 被引量:1
-
6崔剑.新斯的明在心血管手术麻醉中的运用[J].现代医药卫生,2002,18(11):965-966. 被引量:3
-
7李新,宋波,金锡御,李益人,熊恩庆,张煦伟.M受体及其亚型与脊髓横断后逼尿肌反射亢进关系的研究[J].中华泌尿外科杂志,2002,23(8):501-504. 被引量:9
-
8沈瑞林,陈永根,白志强,张大当.胆碱酯酶抑制剂合用α受体阻滞剂治疗部分神经原性膀胱尿道功能障碍[J].河北医学,2000,6(8):701-702.
-
9滕若冰,梁月有,郑克立.M2、M3受体与膀胱逼尿肌关系的研究进展[J].国际泌尿系统杂志,2006,26(5):676-681. 被引量:9
-
10邱建宏,滑丽美,赵新鸿,张世睿,孟晓东,马际尧,吴英,李刚.抗毒蕈碱药物联合阿米替林和中药治疗女性膀胱疼痛综合征[J].临床误诊误治,2012,25(12):81-83. 被引量:1