摘要
应用抗血小板膜糖蛋白抗体、免疫组织化学技术、对１０例骨髓增生异常综合征（ＭＤＳ）骨髓活检组织中巨核细胞（ＭＫ）进行了观察。结果发现：单位面积中ＭＫ数量明显增加，小ＭＫ比例也增加；ＭＫ成簇分布和近骨小梁分布；免疫组织化学染色强度欠均匀一致。这些表现可能有助于骨髓增生异常综合征的诊断和鉴别诊断。
n immunohistochemical study was performed on trephine biopsy specimens of bone marrow in 10 patients with myelodysplastic syndromes(MDS). Monoclonal antibodies HIP_7 and CD_(W41) were used against platelet glycoprotein Ⅱ_b/Ⅲ_a(CD41)to determine dysmegakaryopoiesls including its size,proportion of micromegakaryocytes,location and staining characteristics. The resuIts show that the dysmegakaryopoiesis of MDS includes the increased number and high proportion of micromegakaryocytes, the altered architectural distribution and the considerable variation in staining.These may be helpful in the diagnosis and differential diagnosis of MDS.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
1994年第5期288-290,T057,共4页
Chinese Journal of Pathology
关键词
骨髓增生异常
巨核细胞
免疫组织化学
Myeloproliferative disorderss Megakaryocytes Bone marrow examination Immunohistochemistry
