摘要
目的:探讨肝移植术后丙型肝炎病毒感染的危险因素及处理对策。方法:回顾性分析2001年4月-2005年2月间,复旦大学附属中山医院15例肝移植术后丙型肝炎病毒感染的临床资料,了解相关危险因素、诊断、治疗及预后情况。结果:15例中9例肝移植术后HCV复发,血清中检测到HCVRNA,和(或)出现病理肝活检组织学改变。3例死亡皆因HCV复发不能控制所致。干扰素-α联合利巴韦林治疗4例,HCVRNA血清滴度在治疗后1周皆明显下降。结论:HCV复发是目前肝移植术后一个普遍而又处理棘手的问题。控制并减少HCV复发的危险因素,早期诊断并进行有效的预防和治疗,是提高丙肝肝移植效果的重要途径。
Objective: To study risk factors and treatment of hepatitis C virus (HCV) infection after liver transplantation (LT). Methods: We reviewed the data of 15 HCV-infected patients after LT, in Zhongshan Hospital affiliated to Fudan University, from April 2001 to February 2005. And the correlative risk factors, diagnosis, treatment and prognosis were analyzed retrospectively. Results: 9 of 15 cases were found HCV recurrence after LT, with HCVRNA detected in serum, and/or pathologic change found in liver biopsy. 3 cases all died of uncontrollable HCV recurrence. 4 cases were treated by IFN-α and ribavirin, in all of which the serum level of HCVRNA obviously dropped down 1 week later. Conclusion: Recurrence of HCV infection after LT is a universal but intractable problem. Control and reduce risk factors of HCV recurrence, earlier diagnosis, effective prevention and treatment can improve the effect of LT for hepatitisc.
出处
《中国临床医学》
北大核心
2005年第3期443-445,共3页
Chinese Journal of Clinical Medicine
关键词
肝移植
丙型肝炎
丙肝病毒
复发
Liver transplantation
Hepatitis C
Hepatitis C virus
Recurrence
