摘要
目的:考察西罗莫司在全血中的稳定性。方法:配制浓度分别为2.5,7.5,22.5μg·L-1的西罗莫司血样,在3种温度下(25℃,4℃,-20℃)避光储存0～8d和在-40℃存放后经历3个冻融周期,考察西罗莫司在全血中的稳定性。结果:在3种温度下储存8d和经历3个冻融周期后,西罗莫司血药浓度无显著变化。结论:西罗莫司血样可在冰冻或室温条件保存8d,经历3个冻融周期后西罗莫司在全血中仍能保持稳定。
OBJECTIVETo investigate the stability of sirolimus in whole blood.METHODSAfter preparing sirolimus whole blood samples with concentration of (2.5)、(7.5)、(22.5) μg·L^(-1 ), the effects of storage time (0~8 days) under temperature of (25 ℃),(4 ℃), (-20 ℃) in dark, and freeze-thaw cycles under temperature of (-40 ℃) on the stability of sirolimus in whole blood were examined by HPLC. RESULTSAfter 8 days storage time and three freeze-thaw cycles, the concentration of sirolimus in whole blood had no significant difference. CONCLUSIONSirolimus was stable in whole blood under freeze or at room temperature after 8 days storage time. It was stable in whole blood after three freeze-thaw cycles, too.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2005年第6期532-534,共3页
Chinese Journal of Hospital Pharmacy
