摘要
目的测定“四逆泻心汤”对慢性乙酸型胃溃疡大鼠血清IL-8,胃粘膜SOD含量的影响,探讨其作用机理。方法用乙酸腐蚀法造成慢性乙酸胃溃疡模型后,分别灌胃雷尼替丁、四逆泻心汤及生理盐水,3周后处死动物,取大鼠血清及胃粘膜检测血清IL—8,胃粘膜SOD含量。结果雷尼替丁组、四逆泻心汤组较模型组血清IL—8含量明显降低、胃粘膜SOD含量明显升高。结论四逆泻心汤通过降低溃疡大鼠血清IL—8含量,升高胃粘膜SOD含量达到治疗胃溃疡的目的。
Objection:To investigate the effect of Sini Xiexin Decoction(SNXX)on IL—8 level in serum and SOD level in mucous membrane of stomach in rats of chronic gastric ulcer induced by acetic acid. Methods:After making the rat models of chronic gastric ulcer induced by acetic acid, the model rats were respectively given Ra, SNXX and NS, all rats were killed after 3 weeks, then the contents of IL—8 in serum and SOD in mucous membrane of stomach were measured.Results:The contents of IL—8 in serum in Ra group and SNXX group were significantly lower than those of the model group, and the SOD level in mucous membrane of stomach was significantly higher than that of the model group. Conclusion:SNXX lowers the contents of IL—8 in serum and increases the SOD level in mucous membrane of stomach to cure GU.
出处
《陕西中医学院学报》
2005年第4期52-53,共2页
Journal of Shaanxi College of Traditional Chinese Medicine
