摘要应用罗格列酮治疗大鼠2型糖尿病模型发现,左心室功能的舒张末压和最大舒张期压变化速率比值得到改善,心肌三磷酸腺苷含量升高。In type 2 diabetic rat model, rosiglitazone treatment results in an elevated level of ATP of myocardium and a amelioration of the EDP and-dp/dt_~max of left ventricular function.
1Schannwell CM, Schneppenheim M, Perings S, et al.Left ventricular diastolic dysfunction as an early manifestation of diabetic cardiomyopathy. Cardiology, 2002,98:33-39. 被引量：1
2Reed MJ, Meszaros K, Entes LJ, et al. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism, 2000,49:p1390-1394. 被引量：1
4Belke DD, Larsen TS, Gibbs EM, et al. Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic(db/db) mice. Am J Physiol, 2000,279:E1104-1113. 被引量：1
5Gilde AJ, van der Lee KA, Willemsen PH, et al. Peroxisome proliferators-activated receptor(PPAR) alpha and PPAR beta/delta, but not PPAR gamma, modulate the expression of genes involved in cardiac lipid metabolism. Circ Res,2003,92:518-523. 被引量：1
7Juhaszova M, Rabuel C, Zorov DB, et al. Protection in the aged heart:Preventing the heart-break of old age? Cardiovasc Res, 2005, 66(2): 233-244. 被引量：1
8Bandyopadhyay D, Chattopadhyay A, Ghosh G, et al. Oxidative stress-induced ischemic heart disease: protection by antioxidants. Curr Med Chem, 2004, 11(3):369-387. 被引量：1
9Lee TM, Su SF, Chou TF, et al. Loss of preconditioning by attenuated activation of myocardial ATP-sentive potassium channels in elderly patients undergoing coronary angioplasty. Circulation, 2002, 105(3): 334-340. 被引量：1
10Hara K, Tobe K, Okada T, et al. A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to type Ⅱ diabetes. Diabetologia, 2002, 45(5): 740-743. 被引量：1
