摘要
鼻、咽部的非何杰金淋巴瘤是最常见的一组淋巴结外淋巴瘤，同时，也是在该区的非上皮源性肿瘤中发病率较高的一类疾病。本文对５９例按传统标准诊断的鼻、咽部非何杰金淋巴瘤进行了形态学分类与免疫学分型的比较研究，结果为：（ｌ）本组病例的男女性别之比为２．９：１，中位年龄５１岁，病损处局部形成息肉或结节样新生物是其主要特征；临床Ⅰ期患者占８３％。（２）５９例淋巴瘤的组织学型别构成复杂，高恶性与低、中恶性者各占５０％，约７１。４％的高恶性型非何杰金淋巴瘤是发生在一腔。（３）５９例中，瘤细胞表达Ｂ细胞分化抗原的点５５．９％，检出免疫球蛋白轻链限制性反应的占２１％（７／３３）；表达Ｔ细胞分化抗原的占３７．３％，而其中２／３以上的病例是发生在一腔。说明：在不含中线恶网病例的条件下，鼻腔仍然是非何杰金淋巴瘤的好发部位，且以高恶性型及Ｔ细胞性者为多；而在不含扁桃体的非何杰金淋巴瘤的条件下，发生在鼻咽及口咽部的非何杰金淋巴瘤仍为低、中恶性型及Ｂ细胞性淋巴瘤。还对鼻、咽部非何杰金淋巴瘤的诊断及预后等问题进行了讨论。
Non-Hodgkin's lymphoma (NHL) of nose and pharynx is a group of extra nodal lymphomas most commonly seen and is also a kind of non-epithelial tumor with a relatively high incidence in these regions. A morphologic classification and an immunophenotypic analysis were made for 59 cases of NHL of nose and pharynx diagnosed by the conventional diagnostic criteria. The results showed that(l) the ratio of male to female was 2.9:1,the median age was 5l years old, the main manifestations of the neoplasms were polyps or nodules in the involved regions and 83% of the patients were of clinical stage I:(2) the constitution of morphologic subtypes of this group of lymphomas was complex,about 50% of cases were fallen into subtype with high grade, the remaining 50% into subtype with low or intermediate grade malignancy and about 71.4% of the lymphomas with high grade malignancy occurred in the nasal cavity; and (3) the expression of B-lymphocyte differentiation antigen on tumor cells was found in 55.9% (33/59) of the cases and 21% (7/33)of them showed immunoglobulin light chain restricted reaction and the expression of T-cell differentiation antigen on tumor cells was seen in 37.3% (22/59) of the cases of whom the lymphomas occurring in the nasal cavity were found in two thirds.The results demonstrate that the nasal cavity is still the predilection site of NHL, especially the lymphomas with high grade malignancy and of Tcell type provided that the midline malignant reticulosis is excluded. The NHL occurring in naso - and oro-pharynx is of low or intermediate grade and of B-cell type, if tonsillar lymphomas were not taken into account. The diagnosis and prognosis of NHL of nose and pharynx were discussed.
出处
《诊断病理学杂志》
CSCD
1994年第2期72-74,共3页
Chinese Journal of Diagnostic Pathology
基金
国家自然科学基金
青年基金
纽约中华医学基金
