摘要
应用兔MCAO（middlecarebralarteryocclusion）局灶脑缺血模型，将实验动物随机分成4组：对照组C、脑缺血后2h、4h、24h（I1、I2、I24）组。放免法测定脑组织和血浆中强啡肽含量的时相变化，同时测脑组织H2O、Na+含量。结果发现MCAO后脑组织和血浆强啡肽含量显著增高，且随时相递增，并与脑组织H2O、Na+变化呈正相关。提示强啡肽可能参与脑缺血脑水肿的发生发展。
Using the rabbit model of middle cerebral artery occlusion (MCAO), experimental animals were randomly divided into 4 groups: control group and 2h, 4h,24h groups after cerebral ischemia. Contents of Dynorphin (Dyn A1-13 ) in brain tissue and plasma were determined by RIA, and contents of H2O and Na+ in the brain tissue were also measured. We found that after MCAO, Dyn A1-13 contents increased significantly both in the brain tissue and in plasma.The increment was parallel with the length of ischemia. There were positive correlations between Dyn A1-13, and H2O, Na+. These results suggested that the increased contents of Dyn A1-13, after cerebral ischemia might participate in the developrnent of cerebral ischemic edema.
出处
《急诊医学》
CSCD
1994年第4期131-134,共4页
基金
卫生部"八.五"攻关脑缺血脑水肿课题
关键词
强啡肽
脑缺血
脑水肿
兔
cerebral ischemia
brain edema
rabbit
dynorphin
